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MOA of Sulfronamide (Sulfa Drug) Antibiotics - P2
Virtual Microbiology

You have free access to a large collection of materials used in a college-level introductory microbiology course. The Virtual Microbiology Classroom provides a wide range of free educational resources including PowerPoint Lectures, Study Guides, Review Questions and Practice Test Questions.
Prokaryotic Cell, Mariana Ruiz

Sources & Resources
  • Bauman, R. (2014) Microbiology with Diseases by Taxonomy. Pearson Benjamin Cummings.
  • ​Park Talaro, K (2008) Foundations in Microbiology, McGraw Hill.

Antimicrobial Spectrum of Sulfa Drugs
Sulfonamides have broad spectrum activity against both Gram-positive and 
Gram-negative bacteria.

Type of Infections Sulfa Antimicrobic Drugs are Used Against
Sulfa drugs are used to treat some types of bacterial pneumonia, urinary tract infections, shigellosis, Nocardia infections (a type of bacterium with an unusual waxy cell wall) and specific protozoal infections.

​Page last updated: 8/2015

from the free STEM 
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Science Prof Online
Allergies to sulfonamides are common (about 3% of general population), so sulfa drugs are prescribed carefully. Hypersensitivity reactions are less frequently seen in non-antibiotic sulfonamides. The most common hypersensitivity reaction to sulfa drugs are skin reactions such as rashes and hives. However, there are several types of reactions that can be life-threatening.

Antibiotic Resistance
Bacterial resistance to sulfonamide antibiotics is also common, and sulfa drugs are frequently used in combination with trimethoprim; which blocks two steps in folic acid metabolism, and thus helps prevent the emergence of strains of bacteria resistant to sulfa drugs.

* The information in this article is not meant to be used for self-diagnosis or treatment of illness. If you are sick, seek help from a trained medical professional, not a computer.
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Sulfa Drug Mode of Action
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