MOA of Tetracycline Antibiotics - P2

Sources & Resources
  • Bauman, R. (2014) Microbiology with Diseases by Taxonomy. Pearson Benjamin Cummings.
  • ​Park Talaro, K (2008) Foundations in Microbiology, McGraw Hill.

Type of Infections Tetracyclines Are Used Against
Tetracycline is used to treat many different infections including respiratory tract infections caused by Hemophilus influenzae
Streptococcus pneumoniae, or Mycoplasma pneumoniae. It also is used for urinary tract infections (UTIs), Rocky Mountain spotted fever, typhus, chancroid, cholera, brucellosis, anthrax, syphilis, lyme disease, acne and may be used concomitantly with other medications against Helicobacter pylori, the bacteria associated with stomach ulcers.

Tetracycline molecule ball-and-stick animation.
Tetracycline molecule ball-and-stick animation.
Virtual Microbiology

You have free access to a large collection of materials used in a college-level introductory microbiology course. The Virtual Microbiology Classroom provides a wide range of free educational resources including PowerPoint Lectures, Study Guides, Review Questions and Practice Test Questions.
Prokaryotic Cell, Mariana Ruiz
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Page last updated: 8/2015

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Antibiotic Resistance
Because tetracyclines have been around for so long, bacterial resistance is common, and the presence of tetracycline-resistant pathogens limits the use of this class of antibiotic.

Adverse Effects of Tetracyclines
Side effects may include nausea, diarrhea, and sensitivity to light. Tetracyclines also form complexes with calcium, which can stain the developing teeth of children and affect the strength and shape of bones.

Since tetracyclines are active against such a wide range of microbes, destruction of normal intestinal flora often occurs, resulting in increased secondary infections.

* The information in this article is not meant to be used for self-diagnosis or treatment of illness. If you are sick, seek help from a trained medical professional, not a computer.​